Author Archive: Stephen Green

KRUISER’S MORNING BRIEF: What Did We Learn From the Impeachment Hearing? “Rounding up a few academics to complain about any Republican isn’t exactly a daunting task. That’s like wandering around Hyannis Port in the summertime and bumping into a drunk Kennedy.”

ISN’T THIS KIND OF HOW THE ‘PLANET OF THE APES’ REBOOT GOT GOING? China gene-edited baby experiment ‘may have created unintended mutations.’

Excerpts from the manuscript were released by the MIT Technology Review to show how Chinese biophysicist He Jiankui ignored ethical and scientific norms in creating the twins Lula and Nana, whose birth in late 2018 sent shockwaves through the scientific world.

He made expansive claims of a medical breakthrough that could “control the HIV epidemic”, but it was not clear whether it had even been successful in its intended purpose – immunising the babies against the virus – because the team did not in fact reproduce the gene mutation that confers this resistance.

A small percentage of people are born with immunity because of a mutation in a gene called CCR5 and it was this gene that He had claimed to have targeted using a powerful editing tool known as Crispr which has revolutionised the field since 2012.

Fyodor Urnov, a genome-editing scientist at the University of California, Berkeley told the MIT Technology Review: “The claim they have reproduced the prevalent CCR5 variant is a blatant misrepresentation of the actual data and can only be described by one term: a deliberate falsehood.

“The study shows that the research team instead failed to reproduce the prevalent CCR5 variant.”

While the team targeted the right gene, they did not replicate the “Delta 32” variation required, instead creating novel edits whose effects are not clear.

China has enough knowhow now that they really can’t afford to keep being as reckless as Communist countries usually are.

YEAH, BUT THE PAY IS NICE: Sundar Pichai just got the worst job in Silicon Valley.

Now, after spending the last several years effectively AWOL from the public and much of Alphabet, Page and Brin, both 46, are out just in time for the company to muddle through its biggest challenges in its history.

And poor Pichai has been tasked with navigating Alphabet through all of it, while Page and Brin get to shield themselves from all of the scrutiny and challenges.

But even as the new leader of Alphabet, Pichai is stuck between a rock and a hard place. And Page and Brin will still loom over all of it.

When founders leave, they really ought to leave.

UPDATE (FROM GLENN): Flashback: Google needs a new CEO, but dumping Sundar Pichai is not enough.

DON’T IT MAKE MY RED STATE BLUE: Out of state “dark money” fueled Colorado’s 2018 election; AG Weiser among beneficiaries despite transparency pledge.

The 501(c)(4), spent nearly $11 million on everything from redistricting changes to the state constitution, wage increase propositions, payday loan regulations, conservation issues, opposing Amendment 74 — which would have compensated property owners if government regulations resulted in lowering their property values — and supporting Democrat candidates running for state offices.

Sixteen Thirty Fund spending in Colorado was initially reported by the Colorado Sun, including its connection to Gov. Jared Polis’ race, with more than $900,000 going to Good Jobs Colorado, which supported Polis.

However, Sixteen Thirty Fund’s connection to Weiser, whose campaign benefited from $600,000 in donations to Justice Colorado, as well as many candidates supported by Our Colorado Values, went unnoticed until now.

Our Colorado Values spent $3.3 million statewide supporting myriad candidates including former House District 50 Rep. Rochelle Galindo, who resigned amid sexual assault allegations and is currently awaiting trial for supplying drugs and alcohol to a minor.

Justice Colorado spent $2.347 million entirely on supporting Weiser and opposing his opponent, 18th Judicial District Attorney George Brauchler.

The spending conflicts with one of the main platforms Weiser ran his campaign on —eliminating the ability of nonprofits to donate without disclosing its donors.

That’s different because reasons.

MEANWHILE, OVER AT VODKAPUNDIT: Joe Biden: Just Stupid Enough to Get Away with Being a Thief. “Joe Biden has always been just smart enough to see what he could get away with, and just dumb enough that few believed he could actually be that corrupt — like finding out your favorite Bond supervillain had the IQ of an ashtray.”

The best part? Biden just accused someone else of plagiarism.