Author Archive: Glenn Reynolds

HMM: Are GLP-1s the New Statins? “As their popularity grows, so does the number of health benefits that reach beyond the scale. The most consistent and robust findings seem to be for the heart. In fact, GLP-1s appear to have similar cardiovascular results to statins—a well-established cornerstone of cardiovascular care for decades. But there is one glaring difference: people actually want to take GLP-1s. Despite the expanded use of statins among younger folks, they have grown an unpopular reputation for their potential muscular side effects. Given that the most promising recent cholesterol drug didn’t actually work, is the next pivot toward GLP-1s? And will Ozempic and Mounjaro soon usurp the reign of statins as the go-to heart drug?”

“SMART IN ‘ALTERNATE’ WAYS” IS WHAT DUMB PEOPLE SAY:

JUSTICE:

AS USUAL, ERIC S. RAYMOND NAILS IT:

ILHAN, GO HOME:

OPEN THREAD: Tuesday’s groovy.

ADMIT IT, YOU DIDN’T HAVE TO BE TOLD THIS:

METFORMIN UPDATE: Could a Decades-Old Diabetes Drug Help the Body Age More Slowly?

A cautionary note: While metformin is regarded as quite safe, a reader wrote that he suffered severe and lasting side effects from metformin and a GLP-1 (he didn’t say which one). I tried microdosing Ozempic and then Tirzepatide, which a lot of medical people I know are doing for metabolic and neurological benefits (it’s thought to reduce dementia risk). In my case I found that it raised my resting heart rate from the mid-50s into the low 70s in the case of Ozempic, and the mid 60s with Tirzepatide. That’s a known side effect considered harmless, but I didn’t feel good about it. It also reduced my HRV (Heart Rate Variability) which is possibly bad. I have gone back to normal since going off, but it took a couple of months. (And I wouldn’t have even known absent the Oura Ring, which tracks those things.)