EXCITING BUT SCARY: A “Word Processor” for Genes – Scientists Unveil Fundamentally New Mechanism for Biological Programming. “Arc Institute scientists have discovered the bridge recombinase mechanism, a revolutionary tool that enables fully programmable DNA rearrangements. Their finding, detailed in a recent Nature publication, is the first DNA recombinase that uses a non-coding RNA for sequence-specific selection of target and donor DNA molecules. This bridge RNA is programmable, allowing the user to specify any desired genomic target sequence and any donor DNA molecule to be inserted.”