CHANGE: What Is ‘Ozempic Face’, And Why Is It So Controversial? “It’s known that when significant body weight is rapidly lost, excess skin around the temples, cheeks, eye, jawline, and mouth can sag and wrinkle. Depending on an individual’s diet and hydration, their skin can appear duller, dryer and more wrinkled as body fat drops. What’s more, the use of GLP-1 agonists – regardless of fat loss – can also cause changes to the size of a person’s lips, cheeks and chin. Studies show that patients who experience massive weight loss in general are more likely to look several years older in the face than those who don’t.”

Yes, everyone I’ve known over 50 who has lost a lot of poundage has looked funny for a while. The skin needs time to catch up.