HMM: Monkeypox symptoms in patients attending London clinics differ from previous outbreaks. “The findings suggest that patients in this cohort had a higher prevalence of skin lesions in the genital and anal area and lower prevalence of tiredness and fever than in cases from previously studied outbreaks of monkeypox. The authors also predict that the high prevalence of genital skin lesions in patients and the high rate of co-occurring sexually transmitted infections means that sexual health clinics are likely to see additional monkeypox cases in the future. . . . All except two of the patients in the cohort were not aware of having been in contact with a known case and none reported travel to sub-Saharan Africa, however many had recently visited other European countries. All patients identified as men who have sex with men and there was a median age of 41. 90% of the patients who responded to the questions on sexual activity (47/52) reported at least one new sexual partner during the three weeks prior to symptoms, and almost all (49/52) reported inconsistent condom use in this same time period. Over half of the patients (29/52) had more than five sexual partners in the 12 weeks prior to their monkeypox diagnosis.”