February 27, 2020

WAS THE EXCESSIVE DEATH RATE IN THE 1918 “SPANISH” FLU driven by aspirin overdoses? “The hypothesis presented herein is that salicylate therapy for influenza during the 1918–1919 pandemic resulted in toxicity and pulmonary edema, which contributed to the incidence and severity of early ARDS-like lungs, subsequent bacterial infection, and overall mortality. Pharmacokinetic data, which were unavailable in 1918, indicate that the aspirin regimens recommended for the ‘Spanish influenza’ predispose to severe pulmonary toxicity.”

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