MORE PROTON-PUMP PROBLEMS: Reflux Drugs Tied to Bone Fractures in Children. “After controlling for sex, preterm birth, obesity and other variables, they found that compared with those who did not get them, those given P.P.I.s before age 1 were at a 23 percent increased risk for fracture. There was a 31 percent increased risk when the infants took H2 antagonists at the same time. The risk increased with longer use, but did not rise when H2 antagonists were used alone.”