MAYBE THE DRUGS WORK AS INTENDED BUT THE DISEASE MODELS ARE WRONG: Failure of Alzheimer’s drugs in trials makes researchers wonder what is going wrong. “The basic assumption that removing amyloid will automatically lead to an improvement in Alzheimer’s patients needs to be re-evaluated, said Michael Murphy, an associate professor with the University of Kentucky’s Sanders-Brown Center on Aging. Although the genetic evidence has been convincing that amyloid drives the disease, that doesn’t mean that removing the protein from people already in the throes of Alzheimer’s is going to help them, Murphy said.”