FASTER, PLEASE: Progress, And Momentum, On Doing Something About Aging.
Fifteen years ago, de Grey was lead author of a paper in the Annals of the New York Academy of Sciences which claimed the “indefinite postponement of aging . . . may be within sight”. Since then, he says, his position among gerontologists — the scientists of ageing and its related ills — has changed from sidelined dilettante to one of the discipline’s most influential and public voices.
Most approaches aimed at combating ageing focus on arresting the harmful byproducts of metabolism, he says. These cause cellular damage and decay, which, in turn, accumulate to trigger the age-related disorders, such as cancer or dementia, that tend to finish us off.
For de Grey, this strategy turns anti-ageing treatment into an impossible game of Whac-A-Mole. Because we understand metabolism so poorly, our efforts to interfere with it remain crude and the process of decay races through the body far quicker than treatments to avert it can keep up.
Instead of stopping the damage, the approach that de Grey has developed at his research centre — Strategies for Engineered Negligible Senescence (SENS), a public charity that he co-founded in 2009 — focuses on repair. This “engineering” approach is designed to keep the process of degradation below the threshold at which it turns into life-threatening disease. “If you can repair the microscopic damage then you are sidestepping the bigger problem [of prevention]”.
While his science may now be more widely accepted, his pronouncements of impending immortality remain unpopular among his peers. Their squeamishness is unsupported by the evidence, he says. It belies an intellectual dishonesty that has at its heart a deeply emotional — and increasingly erroneous — attachment to the inevitability of death, according to de Grey.
Historically, accepting the inevitability of death was the rational choice and a necessary requirement, he says, “to get on and make the most of our miserably short lives”. Today, when technology has advanced enough to put us “within striking distance” of extending human life by a multiple of existing lifespans, this acceptance has become a huge obstacle to achieving that goal. The traditional emotional need to accept our own mortality has generated a “pro-ageing trance” which is hobbling even the best scientists from pursuing the enterprise with the ardour it demands.
Well, get over it, guys. I’m not getting any younger here — and neither is anybody else.