TESTOSTERONE GEL INCREASES HEART RISKS. At least in older men with diabetes, etc. Speculation: “The problem is that as we age lots of mechanisms have gone so awry that stimulating them just causes them to go wrong faster. Though another recent study found that ovary transplants improve the health of aged female mice. Those ovaries pump out a lot of hormones and yet they deliver a net benefit. Maybe the reason the transplants deliver a net benefit is that the ovaries excrete multiple kinds of hormones and with hormone release patterns optimized to improve health. Internal organs have complex regulatory mechanisms. Whereas testosterone gels are not released in ways that precisely mimic what the brain will do.”