Archive for 2014

BILL STRAUB: ‘We Need to Quit Acting So Freaking Defeated’: Dems Plot Blue Creep in Deep South. Easy. The way you turn states from red to purple is to make blue states so intolerable that a lot of people flee them for red states. Then those voters stupidly vote for the same disastrous policies in their new homes. So Andrew Cuomo, Martin O’Malley and Jerry Brown are already executing the plan. . . .

I THINK WE NEED AN EXCESS ENDOWMENTS TAX: Universities engage in “endowment hoarding.”

A downturn in the endowment equivalent to a 10% reduction of a university’s budget leads to a 4.9% reduction in the number of tenure-system faculty during the following year relative to similar universities that did not experience shocks to their endowment funds.

A shrinking endowment also results in cuts made to support employees such as secretaries, but found no similar effect on the numbers of adjunct faculty or administrators. All this suggests that that endowments are being used to keep administrators’ jobs safe during economic downturns rather than as means to preserve academic quality of the institution. More broadly, one has to ask what the point of university endowments is if there is such an emphasis on growth—rather than protecting the institutions they were created to benefit. The inability of universities to cut administrative staff when endowments are shrinking is also troubling.

At some point, you’ve hoarded enough money.

DISAPPOINTMENT WITH THE 21ST CENTURY: Today’s Apps Are Turning Us Into Sociopaths.

First, some quick background on how BroApp works: It not only sends scheduled texts, but comes preloaded with 12 messages to help users get started. The developers also took steps to conceal the automation going on behind the scenes; in places designated “no bro zones,” the app is automatically disabled. (After all, the jig is up if your girlfriend received an automatic text from you while you’re at her place.) The app even has a rating system that lowers the risk of the same message being sent too frequently.

Despite the fact that the app currently advertises the core benefit of spending “more time with the bros”, it included other scenarios in the initially testing according to the developers: “A girl who used it to message her boyfriend.” Someone who “used it to message her Mum a few times a week.” But let’s put aside the many gender implications for a moment. There’s certainly much to discuss there, and by no means do I want to dismiss the fact that this type of thing exacerbates power differentials and perpetuates the problem of sexism in the tech industry.

Uh huh.

21ST CENTURY RELATIONSHIPS: Want To Plan A Threesome? There’s An App For That!

UPDATE: I’ve disabled this link because a reader said there was a trojan on the site. It was YourTango, which should be safe, but better safe than sorry.

A 1029-HORSEPOWER minivan.

FASTER, PLEASE: Compound That May Mimic Calorie Restriction Extends Life Span in Mice.

A synthetic chemical that may mimic the effects of eating a low-calorie diet extends life span in mice, a new study has found. Previous research showed that mice on a high-fat diet lived longer when given this compound, known as SRT1720; the new work shows that mice on a standard diet also benefit from it. This study is just the latest in an extensive effort to find compounds that may help slow aging and aging-related diseases. . . .

Recently, scientists have been testing synthetic chemicals that activate sirtuins much more efficiently than resveratrol, including SRT1720. The newest study, published in the February 27 Cell Reports, found that SR1720 extended the life span of mice on a standard diet by about 9 percent. They also confirmed their earlier work indicating that the compound extends the life span of mice fed a high-fat diet.

“I think the data in the paper is compelling,” says sirtuin researcher Leonard Guarente of the Massachusetts Institute of Technology, who is not a co-author of the study, although he is a consultant for a company involved in the research. He acknowledges it is impossible to say for sure that SRT1720 is activating sirtuins and nothing else. But “that qualification would hold for really any pharmacological intervention,” he observes.

It may be a long time before SRT1720 makes it into human medication, however, if it does at all. Even then, it would likely be targeted at specific ailments such as heart disease or diabetes, not longevity, says Rafael de Cabo, a researcher at the National Institute on Aging and the senior author of the paper. “There is no such a disease called ‘aging,’ defined by the F.D.A.,” he says. “You cannot process an application for a drug for curing aging.”

Well, the FDA needs to get its act together.

IN THE MAIL: From Charles E. Gannon, Fire with Fire.