THE GREAT STAGNATION: Growing Input-Outcome Disparity In Biomedical Research. “Why does this matter? Our lives depend on the rate of advance of biomedical treatments. We all have an expiration date on our bodies absent some really big advances in methods to rejuvenate aging bodies. How many decades do you have left to live? Not as many as you would have if only increased spending on biomedical research had translated into a more rapid rate of progress in the development of gene therapies, cell therapies, and other therapies needed for tissue repair and rejuvenation.”